服务热线:400-185-1590
扫一扫

扫一扫

取消
P产品中心Our Products
您所在的位置是:主页 > 产品中心 > 重组蛋白 >
P产品中心Our Products
您所在的位置是:主页 > 产品中心 > 重组蛋白 >
规格单价
100ug2300

Recombinant Human Noggin

Catalog number: RP8018-100

DESCRIPTION
Source

Human embryonic kidney 293 cells, HEK293
Gln28-Cys232, with a stable fusion tag at the C-terminal
UniProtKB# Q13253

Species

Human

Predicted Molecular Mass

    

SPECIFICATIONS
SDS-PAGE

The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) .   

Activity

Measured by its ability to bind BMP2 with Elisa method
Optimal concentrations should be determined by each laboratory for each application.

Endotoxin Level

<1 EU per 1 μg of the protein by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

PREPARATION AND STORAGE
Shipping

The product is shipped with dry ice.

Storage

For long term storage, the product should be stored at lyophilized state at -80°C,avoid repeated freeze­thaw cycles.

Stability

>12 months,under -80°C conditions

DATA
BACKGROUND
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion

友情链接
  • 我们的电话400-185-1590
  • 我们的邮箱techsupport@sgebio.com
  • 我们的地址江苏省苏州市工业园区金鸡湖大道99号纳米城10幢401
  • 我们的微信号bioyong408