Human embryonic kidney 293 cells, HEK293
Ser20Thr643, human FC tag
Predicted Molecular Mass
The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Measured by its ability to HRG-beta by elisa method
<1 EU per 1 μg of the protein by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from a 0.2 μm filtered solution in PBS.
- PREPARATION AND STORAGE
The product is shipped with dry ice.
For long term storage, the product should be stored at lyophilized state at -80°C，avoid repeated freezethaw cycles.
>6 months,under -80°C conditions
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.