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规格单价
100ug2000

Recombinant Human HER3-FC

Catalog number: RP8013

DESCRIPTION
Source

Human embryonic kidney 293 cells, HEK293
Ser20­Thr643, human FC tag
UniProtKB# P21860

Species

Human

Predicted Molecular Mass

94.6 kDa

SPECIFICATIONS
SDS-PAGE

The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Activity

Measured by its ability to HRG-beta by elisa method

Endotoxin Level

<1 EU per 1 μg of the protein by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

PREPARATION AND STORAGE
Shipping

The product is shipped with dry ice.

Storage

For long term storage, the product should be stored at lyophilized state at -80°C,avoid repeated freeze­thaw cycles.

Stability

>6 months,under -80°C conditions

DATA
BACKGROUND
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

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