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规格单价
200ug2000

Recombinant SARS-CoV-2 Spike RBD [Fc]

Catalog number: RP8015

DESCRIPTION
Source

Human embryonic kidney 293 cells, HEK293
Arg328-Phe528, human FC tag
UniProtKB# P0DTC2

Species

Human

Predicted Molecular Mass

53.3

SPECIFICATIONS
SDS-PAGE

The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Activity

Measured by its ability to bind Ace2 by elisa method

Endotoxin Level

<1 EU per 1 μg of the protein by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

PREPARATION AND STORAGE
Shipping

The product is shipped with dry ice.

Storage

For long term storage, the product should be stored at lyophilized state at -80°C,avoid repeated freeze­thaw cycles.

Stability

>6 months,under -80°C conditions

DATA
BACKGROUND
Spike protein S1:attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Can be alternatively processed by host furin (PubMed:32362314). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes

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